Name | Pine bark extract |
Synonyms | Pine Bark Ext. PINE BARK EXTRACT Pine bark extract Pinus massoniana Lamb PINUS PINASTER (DRY EXTRACT) TIANFU CHEM--Pine bark extract |
CAS | 133248-87-0 |
EINECS | 919-848-6 |
Physical and Chemical Properties | The refined pine bark extract is a flowable fine powder, slightly reddish brown, aromatic, and slightly astringent in the population. In the dry environment is very stable, protected from light can be up to 5 years, the loss of procyanidins only 1%. |
Plant source: | Pine bark |
Plant extract | The main component of pine extract is extremely water-soluble oligomeric proanthocyanidins, which can remove excess free radicals in the human body and improve The body's immunity, and has strong antioxidant capacity, can be used as the main active ingredient of anti-cancer, anti-mutation, and cardiovascular disease drugs and as a safe and non-toxic new natural antioxidant, therefore, it has a wide range of uses in the fields of medicine, health care, cosmetics, food, etc. Fig. 1 is pine extract |
active ingredient | the main ingredient of pine bark extract is a mixture of monomers, oligomers and multimers. there are three main types of monomers, namely catechins, epatechins and taxin. Oligomers and multimers are collectively referred to as procyanidins. Proanthocyanidins, referred to as OPC, is a bioflavonoid with a special molecular structure. It is currently internationally recognized as the most effective natural antioxidant for scavenging free radicals in the human body. Fig. 2 shows proanthocyanidins |
physiological effects on different groups | pine bark extract for all people, its anti-aging and antioxidant activities can be seen from the above two classic experiments. For special people, pine bark extract also shows special physiological effects. For women, in addition to the cosmetic effect of pine bark extract, several fruit acid components contained in it have the effect of relieving spasm pain (anti-spasm) and can relieve uterine spasm. The protective effect of pine bark extract on capillaries also helps to further reduce menstrual discomfort. In a study by Takafumi Kohama and Nobutaka Suzuki of Japan's Kanazawa University School of Medicine, some women started taking 30-60mg/d of pine bark extract in the first two weeks of menstruation. After taking it for four weeks, 80% women suffering from endometriosis, 70% suffering from severe dysmenorrhea and 60% having gynecological surgery all had pain relief or completely disappeared. For men, due to the antioxidant and free radical activity of pine bark extract, it can improve male infertility symptoms caused by sperm abnormalities. It also has a certain effect on patients with erectile dysfunction. Durackova et al. conducted a three-month experiment with pine bark extract and placebo on 21 patients with erectile dysfunction. In the experiment, erectile dysfunction is confirmed by the internationally recognized IIEF -5 (international erectile dysfunction index, the highest score is 25,21-25 is normal function, 16-20 is mild disorder, 11-15 is moderate disorder, and less than 10 is serious disorder). The subjects were 22 to 69 years old, and the test dose was 12Omg/day, which was taken orally in three times. Three months later, the IIEF-5 index of the subjects increased from the original average 12.6 1.1 to 16.8 0.8. However, placebo did not improve the IIEF -5 index. Pine bark extract can also inhibit platelet aggregation caused by smoking, improve the memory and learning ability of the elderly, and increase the exercise tolerance of athletes. Since the main component of pine bark extract is proanthocyanidins, proanthocyanidins have the advantages of cardiovascular protection, prevention of high blood pressure, prevention of cancer, enhancement of human immunity, improvement of visual function, etc., pine bark extract should also have. The solubility of pine bark extract in water is very good, it is absorbed well after oral administration, it works quickly into everyone's body, and the effect is maintained for a long time. |
pharmacological action | reducing free radicals in cigarette smoke: adding pine bark extract to filter tip is better than adding the same amount of grape seed extract to reduce the gas phase, granular phase and total free radicals of cigarette, and is also better than adding the same amount of grape seed extract by the same method. Pine bark extract can be used to scavenge free radicals in cigarette smoke. Delaying skin aging: Pine bark extract can eliminate wrinkles, improve sagging and sagging skin, and make skin young. The protective effect of neurons: Pine bark extract may increase the content of antioxidant enzymes in brain tissue, improve the body's antioxidant capacity, scavenge free radicals, cut off lipid peroxidation, and protect the integrity of cell membrane structure and function, So as to resist rotenone-induced reduction of substantia nigra-striatum dopamine and keep striatum dopamine at a normal level; block the abnormal aggregation of α-synuclein and reduce the occurrence of autophagy, and the number of neuronal cells have a positive role in promoting, restore the regularity and integrity of cell morphology, reduce apoptosis and the production of free radicals in the body, and then reduce the pathological damage of brain tissue, slow down the pathological process of Parkinson's disease. |
extraction method | weigh 1000g of dried and impurity-removed pine bark, crush it, pass through a 20-mesh sieve, add 2000mL of 95% industrial ethanol, heat and reflux for 4 hours, filter while hot, add 1000mL of 95% industrial ethanol to the filter residue for extraction twice, and merge the filtrate. The extract is concentrated under reduced pressure to dryness and dried to obtain brown pine bark extract powder. The alcohol extract of the powder was detected by silica gel column chromatography and thin layer chromatography, compared with the standard sample of proanthocyanidin low molecular weight polymer and analyzed by spectral data. The main component was the low molecular weight polymer of proanthocyanidin with a content of 90%. |
Application and Prospect | Pine bark extract also contains more than forty bioactive ingredients that are useful to the human body, including oligomeric proanthocyanidins, protocatechuic acid, vanillic acid, ferulic acid, gallic acid, etc. It is an extremely effective compound antioxidant, it has many effects such as delaying aging, beautifying skin, strengthening blood vessels, protecting heart and brain, improving vision, enhancing memory, improving energy, relieving dysmenorrhea, improving reproduction, etc. Its product Pycnogenol (Pycnogenol) has a number of scientific research patents in the United States, France, China, Japan and other countries, and has three patents in the United States alone, such as delaying aging, protecting the heart and brain, and relieving dysmenorrhea. It is one of the best nutritional supplements proved by the literature so far, and its application prospect is very broad. |
safety toxicological analysis | pine bark extract has been put on the market so far, and there have been no reports that it is allergenic or potentially allergenic to skin and eyes. The results of various experimental animals and experimental systems have proved that the pine bark extract is non-toxic, non-mutagenic, non-carcinogenic, and non-teratogenic. The pine bark extract is safe. More than 2000 clinical studies have shown that pine bark extract has only very slight side effects-slight discomfort in the ventral intestine, but these problems can be solved as long as you take pine bark extract and consume a certain amount of food at the same time. |